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The findings are published in the journal SLEEP

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canadian goose jacket Study Probes Circadian Rhythm Genes for Alzheimer Clues By Traci PedersenA certain gene variant previously implicated in employees with a poor tolerance to shift work may also be tied to a greater risk for Alzheimer’s disease in the elderly, according to a new Finnish study.The findings are published in the journal SLEEP.Alzheimer’s disease is a brain disorder that destroys memory and thinking skills over time. Some of browse this site its risk factors include disruption of sleep and the circadian canada goose premium outlet rhythm, issues which are also quite common among shift workers.Tolerance to the negative effects of shift work varies between individuals and is known to be partially linked to intrinsic genetic factors.The study, led by Professor Tiina Paunio at the University of Helsinki and the National Institute for Health and Welfare in Finland, showed that in addition to Alzheimer diagnosis, the melatonin receptor 1A (MTNR1A) gene variation is linked to brain lesions visible in postmortem brain tissues.Furthermore, when the expression of the MTNR1A gene was reduced in the cell culture, beta amyloid canada goose outlet winnipeg address protein characteristic of Alzheimer disease started to accumulate.In a canada goose outlet england previous study, the researchers found that the same gene variation that predisposes to shift work fatigue is associated with lower levels of the MTNR1A gene expression in the brain. This means that the previous findings are compatible with the new findings made in the epidemiological cohorts and cell cultures.The circadian rhythm regulates the release of melatonin, which in turn supports the circadian rhythm through its receptors canadian goose jacket.

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